How Subtle Changes Can Make a Difference: Reproducibility in Complex Supramolecular Systems

Abstract The desire to construct complex molecular systems is driven by the need for technological (r)evolution and our intrinsic curiosity comprehend origin of life. Supramolecular chemists tackle this challenge combining covalent noncovalent reactions leading multicomponent with emerging complexity. However, synthetic strategy often coincides difficult preparation protocols a narrow window suitable conditions. Here, we report on unsuspected observations group that highlight impact subtle “irregularities” supramolecular systems. Based effects pathway complexity, minute amounts water in organic solvents or small impurities building block, discuss potential pitfalls study This article intended draw attention overlooked details initiate an open discussion importance reporting experimental increase reproducibility chemistry.